functionalization of mwnt-cooh by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer

aim : in this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate. background : functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study. patients and methods : mwnt-cooh was functionalized by this compound with one-step reaction that is a new class in modification. product has been investigated by ft-ir, raman and sem. anti cancer investigation with human gastric cells and mtt assay test for measurement of viable cell numbers were also performed. results : the two bands at around 2800–2900 cm -1 which are seen in functionalized product are attributed to the ch stretching of mwnt–cooh defects. conclusion : cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.